Sacrifice tells the story of Dr. Tora Hamilton (Radha Mitchell) and her husband Duncan (Rupert Graves) who move to the Shetland Islands off the coast of Scotland with the hope of adopting a baby from the local adoption agency. Shortly after moving, Tora discovers the body of a woman with mysterious runes carved into her back and her heart torn out buried on her property. Despite being told to leave it alone, Tora decides to try to uncover the identity of who this woman was and who killed her. Could something sinister be lurking on the island?